H2N2V1, Main, Exploration, bibRecord, 002924

Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Identifieur interne : 002924 ( Main/Exploration ); précédent : 002923; suivant : 002925

Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Auteurs : A. E. J. Evans [Royaume-Uni] ; R. L. L. Simmons ; R. D. Ferris ; S. K. Hasell ; E. Letley ; D. S. Freestone

Source :

Journal of Hygiene [ 0022-1724 ] ; 1979-06.

RBID : ISTEX:6CE28AB3D7E6B34AB65C2207CA56C7538ED8D9BF

Abstract

Intranasal vaccination with a single 0·5 ml dose of 107.0 EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAT) antibody in 60 (64·5 %) of 93 volunteers, or in 58 (74·4%) of 78 volunteers with HAI antibody titres before vaccination of ≤ 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6·9 %) of 58 volunteers, or in 3 (14·3%) of 21 volunteers with antibody titres before vaccination of ≤ 1/20. Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.

Url:

https://api.istex.fr/ark:/67375/6GQ-SMPQK3C9-5/fulltext.pdf

DOI: 10.1017/S0022172400054012

Affiliations:

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Le document en format XML

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<author><name sortKey="Letley, E" sort="Letley, E" uniqKey="Letley E" first="E." last="Letley">E. Letley</name>
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<front><div type="abstract">Intranasal vaccination with a single 0·5 ml dose of 107.0 EID 50 WRL 105 strain live influenza vaccine elicited four-fold or greater increases in circulating homotypic haemagglutinating inhibiting (HAT) antibody in 60 (64·5 %) of 93 volunteers, or in 58 (74·4%) of 78 volunteers with HAI antibody titres before vaccination of ≤ 1/20. In comparison, in a group of volunteers vaccinated 9 months previously re-vaccination elicited antibody responses in only 4 (6·9 %) of 58 volunteers, or in 3 (14·3%) of 21 volunteers with antibody titres before vaccination of ≤ 1/20. Titres of vaccine-induced antibody and antibody resulting from earlier natural infection appeared to fall slowly and at equivalent rates over a 9 month period.</div>
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<name sortKey="Hasell, S K" sort="Hasell, S K" uniqKey="Hasell S" first="S. K." last="Hasell">S. K. Hasell</name>
<name sortKey="Letley, E" sort="Letley, E" uniqKey="Letley E" first="E." last="Letley">E. Letley</name>
<name sortKey="Simmons, R L L" sort="Simmons, R L L" uniqKey="Simmons R" first="R. L. L." last="Simmons">R. L. L. Simmons</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Evans, A E J" sort="Evans, A E J" uniqKey="Evans A" first="A. E. J." last="Evans">A. E. J. Evans</name>
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Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Antibody responses to vaccination with WRL 105 strain live influenza vaccine in previously vaccinated and unvaccinated volunteers

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri